Research Activities

08/27/09

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Research activities


I have continued my work on biosensors since 2000 when I started my Ph.D. on development of clinical and environmental sensors at Bhabha Atomic Research Centre, Mumbai, India and had a close collaboration with Indian Institute of Technology, Bombay. During my brief postdoc tenure at Indian Institute of Technology, Bombay and in about two years as postdoc at Myongji University, South Korea I was engaged in designing portable biosensors for clinical applications, while leading a research team comprising of Ph.D. and undergraduate students. In the span of time I successfully completed a number of academic interest projects on design and development of biosensors (mainly standalone bench-top prototypes) and finding new immobilization matrices and stabilization of biomaterials therein. Those projects include:

•Development of integrated microfluidic lab-on-a-chip device for cell lysis, PCR and capillary electrophoresis amperometric detection of PCR amplicon.
•Development of capillary electrophoresis amperometric detectors against dopamine, catechol and endocrine disruptors.
•Development of PDMS based micropump and microvalve for integration onto PCR lab-on-a-chip.
•Development of optical (methyl parathion), potentiometric (urea), amperometric (glucose and catalase), conductometric (urea) and capacitive (creatine kinase -MB) biosensors.
•Projects related to immobilization and stabilization of enzymes and microbial cells in electrochemically and radiation polymerized synthetic polymers such as polyaniline, polypyrrole, polyHEMA and copolymers of polyacrylamide and polyvinyl alcohol.
•Interfacing of analogue electronics to digital environment using LabView based virtual instruments for performing signal acquisition, conditioning and analysis.
•Fabrication of computer controlled dissolved oxygen meter, sensitive to parts per trillion, for assay of catalase in pathological samples, cell and tissue preparations and for developing multi-purpose benchtop glucometer.
•Fabrication of silicon based interdigitated capacitive biosensor (creatine kinase -MB).
•Development of computer controlled pH meter, sensitive to ninth decimal of pH, for standalone potentiometric clinical urea biosensor.

A number of these works have already found place in SCI publications and remainder of them are under circulation or preparation.
 

I also have worked on routine molecular biology; clinical biochemistry and microbiological analysis techniques; isolation and maintenance of all cell types including microbial, animal cell lines and plant tissue cultures and also production, characterization and purification of enzymes. Apart from them I am basically a chemist (First class Honours graduate from University of Calcutta) and hence possess strong analytical skills which were evident from my experience with polymer and enzyme chemistry.
 


I worked under guidance of following eminent scientists

Prof. Yong-Sang Kim, Department of Nanoscience and Engineering, Myongji University, Yongin, South Korea

Prof. Dr. S. F. D'Souza, Associate Director, Bioscience Group, Bhabha Atomic Research Center, Trombay, Mumbai, 400085, E-mail: sfdsouza [at] barc.gov.in Phone: +91-22-2559-3632
Prof. A. Q. Contractor, Head, Department of Chemistry, Indian Institute of Technology, Powai, Mumbai, 400076, E-mail: aqcontractor [at] iitb.ac.in Phone: +91-22-2576-7151

Dr. S. K. Apte, Associate Director (B), Bioscience Group, Bhabha Atomic Research Centre, Trombay, Mumbai, Maharashtra, India. 400085. E-mail: aptesk [at] barc.gov.in Phone: +91-22-25595342
Prof. V. R. Rao, Department of Electrical Engineering, Indian Institute of Technology Bombay, Mumbai, India

Prof. S. Mukherji, Associate Professor, Biomedical Engineering Group, Indian Institute of Technology, Powai, Mumbai, 400076, E-mail: mukherji [at] iitb.ac.in Phone: +91-22-2576-7767

Dr. (Mrs.) Anita Topkar, Scientist, Electronics Division, Bhabha Atomic Research Center, Trombay, Mumbai, 400085, E-mail: anita [at] barc.gov.in Phone: +91-22-7652-2059
Dr. (Mrs.) Aruna Bhatia, Head, Department of Biotechnology, Punjabi University, Patiala, Punjab
Prof. Chanchal Mitra, Department of Chemistry, Hyderabad Central University, Hyderabad, Andhra Pradesh
Prof. Pinaki Sar, Department of Biotechnology, Indian Institute of Technology, Kharagpur, West Bengal 

And of course with many other scientists and engineers, who happens to be my colleagues and mentor and guide on several occasions.
 

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This site was last updated 08/27/09